| 乙醇对大鼠心肌动作电位及人Kv1.5通道的影响 |
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| 作者姓名： | Hu H Zhou J Sun Q Yu XJ Zhang HL Ma X Liu CH Zang WJ |
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| 作者单位： | 西安交通大学医学院药理学系; |
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| 基金项目： | supported by grants from the National Natural Science Foundation of China(No.30930105;No.30873058); the National Basic Research Development Program of China(No.2007CB512005); the Science and Technology Research and Development Project of Shaanxi Province,China(No.2008k13-04) |
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| 摘 要： | 为了研究乙醇对心肌动作电位的作用及其机制,本实验采用标准玻璃微电极细胞内记录技术记录离体大鼠心肌细胞的动作电位(action potential,AP),采用全细胞膜片钳技术记录HEK293细胞上表达的人Kv1.5(human Kv1.5,hKv1.5)通道电流,观察6.25、12.5、25.0、50.0、100.0及...
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| 关 键 词： | 乙醇 心肌 动作电位时程 Kv1.5通道 |
Effects of ethanol on action potential of rat myocardium and human Kv1.5 channel |
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| Hu H,Zhou J,Sun Q,Yu XJ,Zhang HL,Ma X,Liu CH,Zang WJ.Effects of ethanol on action potential of rat myocardium and human Kv1.5 channel[J].Acta Physiologica Sinica,2011,63(3):219-224. |
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| Authors: | Hu Hao Zhou Jun Sun Qiang Yu Xiao-Jiang Zhang Hong-Li Ma Xin Liu Chuan-Hao Zang Wei-Jin |
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| Institution: | HU Hao,ZHOU Jun,SUN Qiang,YU Xiao-Jiang,ZHANG Hong-Li,MA Xin,LIU Chuan-Hao,ZANG Wei-Jin* Department of Pharmacology,School of Medicine,Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | The purpose of the present study was to investigate the effects of different concentrations of ethanol on action potential(AP) in the isolated rat myocardium and the possible mechanism of electric-physiological changes.Standard microelectrode technique was used to record AP in isolated rat myocardium,and whole cell patch clamp technique was used to record the human Kv1.5(hKv1.5) channel currents in HEK293 cells.The effects of different concentrations of ethanol(6.25,12.5,25.0,50.0,100.0 and 200.0 mmol/L) on... |
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| Keywords: | ethanol myocardium action potential duration Kv1 5 channel |
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