| 下行易化系统及其参与神经病理痛的机制 |
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| 作者姓名： | Liu FY Xing GG Qu XX Zhang Z Wan Y |
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| 作者单位： | 1. 北京大学神经科学研究所、神经生物学系;教育部和卫生部神经科学重点实验室,北京,100083
2. 北京大学神经科学研究所、神经生物学系 |
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| 基金项目： | 国家自然科学基金
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北京市自然科学基金
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国家重点基础研究发展计划(973计划) |
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| 摘 要： | 神经病理痛是指由中枢或外周神经系统损伤或疾病引起的疼痛综合征.神经病理痛是临床上常见的一种疾病,但是其发病机制不甚清楚,临床上也缺乏有效的治疗手段.近年来的研究除了集中于痛觉的上行传导及中枢机制,以及痛觉的下行抑制之外,也证明下行易化系统激活参与神经病理痛的发病机制.本文拟对此进行综述,希望为治疗神经病理痛提供新思路.
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| 关 键 词： | 神经病理痛 下行易化系统 延脑头端腹内侧核群 下行易化 神经系统损伤 神经病理痛 中枢机制 Neuropathic Pain Development Role System 治疗手段 活参 下行抑制 传导 上行 研究 发病机制 临床 疼痛综合征 疾病 |
Descending facilitation system and its role in the development of neuropathic pain |
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| Liu FY,Xing GG,Qu XX,Zhang Z,Wan Y.Descending facilitation system and its role in the development of neuropathic pain[J].Progress in Physiological Sciences,2008,39(2):101-104. |
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| Authors: | Liu Feng-Yu Xing Guo-Gang Qu Xiao-Xiu Zhang Zhong Wan You |
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| Institution: | Neuroscience Research Institute, Peking University, China. |
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| Abstract: | Neuropathic pain refers to pain that originates from pathology of the nervous system. Currently available therapies yield limited success in treating such pain, suggesting the need for new insight into its underlying mechanisms. Neuropathic pain involves not only ascending pain pathway and its central modulation, but also descending inhibition and descending facilitation systems. In this review, we introduce briefly the concept of descending facilitation and its role in the development of neuropathic pain. Understanding the descending facilitation system can provide new insights into the modulation of neuropathic pain, and lead to the development of novel therapeutic approaches for the treatment of neuropathic pain. |
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