Computer-linked HPLC system for feedback control of fermentation substrates |
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| Authors: | Jeremy J Mathers Robert C Dinwoodie Martin Talarovich David W Mehnert |
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| Institution: | (1) Kraft, Inc. Research and Development, 801 Waukegan Rd., 60025 Glenview, IL |
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| Abstract: | Summary A data acquisition/control microcomputer system was interfaced to a commercial HPLC data transmission module. Control of substrate (ethanol) levels for four 7.5 L fermenters containing 100 g/L wet weight of the yeastCandida
norvegensis was accomplished by employing intermittent, automated HPLC monitoring and a BASIC-encoded proportional integral policy for controlling substrate feed rates. Ethanol levels were maintained at 0.25, 0.50, 0.75 and 1.00% w/v. |
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