α-Hydroxyacid Oxidase Genetics in the Mouse: Evidence for Two Genetic Loci and a Tetrameric Subunit Structure for the Liver Isozyme |
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| Authors: | John Duley and Roger S Holmes |
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| Institution: | Department of Biochemistry, La Trobe University, Bundoora, 3083, Victoria, Australia |
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| Abstract: | We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure. |
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