Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents |
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| Authors: | Lam Thanh Ling Taotao Chowdhury Chinmay Chao Ta-Hsiang Bahjat F R Lloyd G K Moldawer Lyle L Palladino Michael A Theodorakis Emmanuel A |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA. |
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| Abstract: | The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression. |
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