Effect of toxins produced by various Clostridium difficile strains on cecum size reduction in gnotobiotic mice |
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| Authors: | S Mahé G Corthier |
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| Institution: | Institut national de la recherche agronomique, Centre de recherches de Jouy-en-Josas, France. |
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| Abstract: | Inoculation of axenic mice with Clostridium difficile strains induced a significant reduction in ceca weight (dry or wet), whereas a nontoxinogenic strain led to a partial reduction. A strain, which produces cytotoxin and no enterotoxin in vivo, caused a reduction similar to that observed with a nontoxinogenic strain. Simultaneous cytotoxin and enterotoxin production by various C. difficile strains caused the cecum size to diminish to that observed for conventional control mice. |
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