Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents |
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| Authors: | Poreddy Amruta R Schall Otto F Marshall Garland R Ratledge Colin Slomczynska Urszula |
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| Institution: | MetaPhore Pharmaceuticals, Inc., 1910 Innerbelt Business Center Drive, Saint Louis, MO 63114, USA. |
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| Abstract: | A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a-d, with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium. |
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