外泌体靶向递药在肿瘤治疗中的进展

外泌体是由细胞分泌、粒径为30～ 150 nm的纳米囊泡.外泌体具有优越的生物相容性、良好的载药功能以及便于修饰的膜表面,是一种具有潜力的药物递送载体.在肿瘤治疗研究中,可利用具有靶向识别功能的外泌体来降低脱靶效应,减少不良反应,达到增强治疗效果的目的 .归纳了用不同修饰方法增强外泌体靶向性的研究进展,总结了近五年来利...

Progress of Using Exosome for Drug Targeted Delivery in Tumor Therapy

Exosomes are nano-vesicles secreted by cells with diameter ranging from 30 to 150 nm. Attributed to superior biocompatibility, excellent loading capacity and membrane ease to be functionalized, exosomes are considered to be a promising drug delivery carrier. Among the study of tumor therapy, exosomes with targeted recognition can be used to reduce off-target effects so as to enhance the therapeutic effect. The research progresses of different modification methods to enhance the targeting ability of exosomes were concluded, the recent research using exosomes as specific drug delivery carrier to target tumor cells was summarized, and the advantages and disadvantages of exosomes as rising drug delivery carrier, which provide feasible directions and strategies for the designing of exosomes equipped with targeting specific ability were elaborated.