Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia |
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| Authors: | Eytan Wine Juan C Ossa Scott D Gray-Owen and Philip M Sherman |
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| Institution: | (1) Research Institute, Hospital for Sick Children, 555 University Avenue, M5G 1X8 Toronto, Ontario, Canada;(2) Department of Molecular Genetics, University of Toronto, 1 King's College Circle, M5S 1A8 Toronto, Ontario, Canada;(3) Department of Pediatrics, Division of Gastroenterology and Nutrition, University of Alberta, 11402 University Avenue, T6G 2J3 Edmonton, Alberta, Canada |
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| Abstract: | Background Although bacteria are implicated in the pathogenesis of chronic inflammatory bowel diseases (IBD), mechanisms of intestinal
injury and immune activation remain unclear. Identification of adherent-invasive Escherichia coli (AIEC) strains in IBD patients offers an opportunity to characterize the pathogenesis of microbial-induced intestinal inflammation
in IBD. Previous studies have focused on the invasive phenotype of AIEC and the ability to replicate and survive in phagocytes.
However, the precise mechanisms by which these newly identified microbes penetrate the epithelial lining remain to be clarified.
Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial
monolayers as a contributor to intestinal injury in IBD. |
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