The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K |
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| Authors: | Mitsuru Sakaizumi Yasuhiro Hashimoto Akemi Suzuki Tamio Yamakawa Yoshihiro Kiuchi Kazuo Moriwaki |
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| Institution: | (1) The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, 113 Bunkyo-ku, Tokyo, Japan;(2) National Institute of Genetics, Mishima, Shizuoka, 411, Japan |
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| Abstract: | The polymorphic variation of liver GM1 (NeuGc) ganglioside was found in inbred strains of the mouse. The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1. Since our previous study on H-2 congenic mice indicated that Ggm-1 was linked to the H-2 complex, in this study we measured recombination frequencies among Ggm-1, Go-1 and H-2K in the backcross progeny between (C57BL/10 × SWR)F1 and C57BL/10. Ggm-1 was mapped 1 cM centromeric to H-2K on chromosome 17.Abbreviations used in this paper GM1(NeuGc)
Gal 1-3GalNAc1-4 (NeuGc 2-3)Gal1-4Glc1-ceramide
- GM2(NeuGc)
Gal1-4(Neu Gc2-3)Gal1-4Glc1-ceramide
- GM3(NeuGc)
NeuGc2-3Gal1-4 Glc1-ceramide
- GD1a(NeuGc)
NeuGc2-3Gal1-3GalNAc1-4 (NeuGc2-3)Gal1-4Glc1-ceramide |
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