Effect of end-stage renal disease and diabetes on zinc and copper status |
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Authors: | Maria Nazaré Batista Lílian Cuppari Lucia de Fátima Campos Pedrosa Maria das Graças Almeida José Bruno de Almeida Anna Cecília Queiroz de Medeiros Maria Eugiènia F Canziani |
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Institution: | 1. Division of Nephrology, Federal University of S?o Paulo, S?o Paulo, Brazil 2. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil 3. Department of Clinical and Toxicologicals Analysis, Federal University of Rio Grande do Norte, Natal, Brazil 4. Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, Brazil 5. Health Sciences Post-Graduation Program, Federal University of Rio Grande do Norte, Natal, Brazil
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Abstract: | The aim of this study was to compare the nutritional status of zinc and copper in patients with and without diabetes submitted
to chronic hemodialysis. Thirty-three patients with type 2 diabetes (DM group), 30 nondiabetic patients (NDM group), and 20
healthy individuals (control group) were studied. Plasma, erythrocyte, and urinary zinc and plasma copper were obtained from
atomic absorption spectrophotometry and ceruloplasmin by immunonephelometry. The anthropometric parameters were similar among
the groups. Plasma zinc was lower and erythrocyte zinc was higher in the DM and NDM groups in relation to the control group.
No difference in urinary zinc was observed comparing the groups. Plasma copper was higher in the DM group when compared to
the NDM and control groups. Ceruloplasmin was similar in the three groups. Serum urea was a positive independent determinant
of plasma zinc concentrations. The determinants of erythrocyte zinc were MAMC midarm nuscle circumference and Kt/V dialysis
adequacy. The determinants of plasma copper concentration were serum creatinine and serum glucose. The results of this study
demonstrate an alteration in the distribution of zinc of patients with chronic kidney disease (CKD) independently of the presence
of DM. Also, the status of copper seems not to be influenced by CKD, but only by the metabolic derangements associated with
diabetes. |
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Keywords: | Zinc copper chronic kidney disease hemodialysis diabetes |
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