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Cyclic AMP response in cells exposed to electric fields of different frequencies and intensities
Authors:G. Knedlitschek  M. Noszvai-Nagy  H. Meyer-Waarden  J. Schimmelpfeng  K. F. Weibezahn  H. Dertinger
Affiliation:(1) Institut für Toxikologie, Kernforschungszentrum Karlsruhe, Postfach 3640, D-76021 Karlsruhe, Germany
Abstract:The action on intracellular cyclic AMP (cAMP) of therapeutically used 4000-Hz electric fields was investigated and compared with 50-Hz data. Cultured mouse fibroblasts were exposed for 5 minutes to 4000-Hz sine wave internal electric fields between 3 mV/m and 30 V/m applied within culture medium. A statistically significant decrease in cellular cAMP concentration relative to unexposed cells was observed for fields higher than 10 mV/m. The drop in cAMP was most pronounced at lower field strengths (71 % of controls at 30 mV/m) and tended to disappear at higher field strengths. An increase of cAMP content was observed with 50-Hz electric fields, as was also the case when 4000-Hz fields were modulated with certain low frequencies.
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