Cell polarity and actin mRNA localization |
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| Authors: | Lavoie Brigitte Basyuk Eugenia Bordonné Rémy Bertrand Edouard |
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| Affiliation: | Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, 36 Convent Dr, MSC 4066, Bethesda, MD 20892, USA. lavoieb@ninds.nih.gov |
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| Abstract: | In many species, intracellular mRNA localization is linked to cell polarity. In many cases however, mRNAs become localized as a result of a pre-existing cell-polarity, and they do not modify it. Remarkably, in the case beta actin mRNA in vertebrate, it has been shown that the transport and localization of this RNA is required for the establishment and maintenance of cell polarity. This occurs in fibroblasts, but, very interestingly, in immature neurons as well. This review will describe the functions and mechanisms of actin mRNA localization. |
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