Preparation of 3-bromo-l-tyrosine and 3,5-dibromo-l-tyrosine |
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| Authors: | Robert S Phillips Susan Busby Leia Edenfield Kevin Wickware |
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| Institution: | 1. Department of Chemistry, University of Georgia, Athens, GA, 30602, USA
2. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA
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| Abstract: | l-Tyrosine is converted to 3-bromo-l-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-l-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-l-tyrosine or 3,5-dibromo-l-tyrosine. |
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