Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families |
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Authors: | Luigi Longobardo Nunzia Cecere Marina DellaGreca Ivan de Paola |
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Institution: | 1. Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cinthia 4, 80126, Naples, Italy 2. Dipartimento delle Scienze Biologiche, Università degli Studi di Napoli Federico II, Via Mezzocannone 16, 80134, Naples, Italy
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Abstract: | Natural l-homocysteine and l,l-cystathionine, along with a series of unnatural analogues, have been prepared from l-aspartic and l-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of l-cysteine and potassium thioacetate. |
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