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Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption
Authors:Hütter Eveline  Renner Kathrin  Jansen-Dürr Pidder  Gnaiger Erich
Affiliation:(1) Institute for Biomedical Aging Research, Austrian Academy of Sciences, Peter-Mayr-Str. 4b, A-6020 Innsbruck, Austria;(2) Tyrolean Cancer Research Institute, Innrain 66, A-6020 Innsbruck, Austria;(3) Department of Transplant Surgery, D. Swarovski Research Laboratory, University Hospital Innsbruck, Anichstrasse 35, A-6020 Innsbruck
Abstract:Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone-and antimycin A-inhibited oxygen consumption in the high-oxygen range. This suggests an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen affinity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression of oxygen pressure induces energetic stress under hypoxia.
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