妊娠高血压外周血中促Th2的细胞因子水平及IL-2／IL-10平衡的临床意义

目的：检测妊娠高血压患者外周血中促Th2的分子IL-4、IL-2与IL-10的水平，探讨IL-2／IL-10在妊高症中的临床意义。方法：选择40例未妊娠妇女为对照组，30例正常妊娠妇女为妊娠组，28例妊娠高血压患者为妊娠高血压组，ELISA检测血清中IL-4、IL-2和IL-10的水平。结果：与对照组外周血中IL-4水平（0．53±0．04）pg／ml相比：正常妊娠组IL-4水平升高至（0．91±0．03）pg／ml（P〈0．05），妊娠高血压组IL-4水平（0．67±0．35）pg／ml升高但明显低于正常妊娠组（P〈0．01）。与对照组外周血中IL-2水平（0．41±0．05）pg／ml相比：正常妊娠组IL-2水平升高至（0．82±0．11）pg／ml（P〈0．01）；妊娠高血压组IL-2水平高达1．57±0．22（pg／m1）明显高于其它两组（P〈0．01）。妊娠高血压组外周血中IL-10水平明显低于正常妊娠组IL-10水平（P〈0．01）；妊娠高血压组外周血中IL-2／IL-10比值明显高于于对照组及正常妊娠组的比值。结论：妊娠高血压患者外周血中细胞因子IL-2和IL-10分泌异常且诱导Th2细胞产生的IL-4降低，打破Th1／Th2平衡，致使Th1型免疫反应增强，使早孕期滋养细胞受到免疫损伤以致侵入能力下降，导致妊娠期高血压疾病的发生。

Detection of Levels of IL-2/IL-10 and Promoting Th2 Molecular IL-4 in Peripheral Blood of Gestational Hypertension

Objective： To detect the levels of IL-4 and IL-2 and IL-10 in the patients with pregnancy-induced hypertension, and discuss the detection of IL-2/IL-10. Methods： Taking 40 cases of non-pregnant women as control group, 30 normal pregnant women as pregnancy group, 28 cases of pregnancy induced hypertension as pregnancy-induced hypertension group patients, we used ELISA to detect the levels of IL-4, IL-2 and IL-10 in their serum. Results： The levels of IL-4 in peripheral blood of pregnancy group was （0.91± 0.03） pg / ml, significantly higher than the level of IL-4 （0.53 ± 0.04） pg / ml in control group （P〈0.05）. The levels of IL-4 in peripheral blood of pregnancy-induced hypertension group was （0.67± 0.35） pg / ml, significantly lower than the IL-4 level in normal pregnancy group （P〈0.01）. IL-2 levels of （0.82±0.11） pg / ml in normal pregnancy group was higher than those of （0.41±0.05） pg / ml in control group; IL-2 levels of pregnancy-induced hypertension group was 1.57 ± 0.22 （pg / ml）, significantly higher than that in the control group and normal pregnancy group （P 〈0.01）. IL-10 in peripheral blood during pregnancy was significantly higher. IL-10 levels of pregnancy-induced hypertension was significantly lower than that in normal pregnancy group （P 〈0.01）; the IL-2/IL-10 ratio in pregnancy-induced hypertension group was significantly higher than that in the control group and the normal pregnancy group. Conclusion： IL-2 and IL-10 secretion were abnormal in pregnancy-induced hypertension in patients, and the IL-4 level which could induced the produce of Th2 cells was decreased, then the Th1/Th2 balance was break, making the Thl-type immune response increased, but the invasive capacity decroased of the first trimester trophoblast cells which was injured by immune response, finally resulting in the occurrence of pregnancy induced hypertension.