溶瘤腺病毒在肿瘤靶向治疗中的研究进展

溶瘤腺病毒是一组通过基因工程构建的腺病毒、能够选择性在肿瘤细胞中完成感染-复制周期,从而特异性地杀伤、溶解肿瘤而不伤及其他正常细胞、组织,其作用机制包括：通过基因的缺失突变、插入特异性启动子、以及通过病毒结构蛋白的修饰等方面,实现肿瘤靶向治疗作用。本文就相关研究及进展进行综述。

Progress of Target Therapy with Oncolytic Adenovirus for Cancer

Oncolytic adenovirus is a group of adenovirus,which constructed through genetic engineering.It can execute infec-tion-replication cycle in tumor cells selectively,which specifically kill,dissolve tumors without harming normal cells,tissues.Its mecha-nisms include：the gene deletion mutants,inserted into specific promoter,and as well as through the modification of viral structural pro-teins,etc,to achieve targeted cancer therapy.In this review,oncolytic adenovirus for targeted cancer therapy research and progress are in-troduced.