食管鳞癌组织中的神经纤维分布

目的：探讨食管鳞癌组织中神经纤维的分布情况。方法：应用免疫组化ABC法,探查手术切除的食管鳞癌组织里S100及GAP-43阳性神经纤维的分布情况,并分析其与患者临床病理参数的关系。结果：相对于正常组织,食管鳞癌组织中存在相当数量的S100及GAP-43阳性神经纤维（束）不规则地分布于肿瘤细胞之间,且S100阳性纤维密度大于GAP-43阳性纤维密度;统计分析显示肿瘤组织中纤维密度与患者的肿瘤大小、淋巴结转移相关。结论：食管鳞癌组织中确实存在神经纤维分布,并对肿瘤发展起一定作用。

Nerve Fiber Distribution in Esophageal Squamous Cell Carcinoma

Objective： The aim of this study was to investigate the arrangement and pathological significance of immunoreactive nerve fibers in the tumor mass of human esophageal squmous cell carcinoma（ESCC）.Methods： Frozen sections were processed for im-munohistochemistry staining to detect the distribution of the intratumoral nerves visualized by antibodies against S100 and growth associ-ated protein 43（GAP-43）.Results： The microscopic observations revealed plenty of S100 positive fibers and relatively minor GAP-43 positive fibers in the intratumoral zone.The statistical analysis demonstrated a significantly association between the two kinds of nerve fiber and grade of tumor invasion.Conclusion： Our results indicated a novel concept that nerve fibers were really existed in the tumoral area and some of them were regenerated.In addition,the distribution of nerve fibers was correlated with the depth of tumor invasion.