| RASSF6与肿瘤研究进展 |
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| 引用本文： | 温玉刚,王权,彭志海.RASSF6与肿瘤研究进展[J].生物磁学,2011(13):2590-2593. |
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| 作者姓名： | 温玉刚 王权 彭志海 |
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| 作者单位： | 上海交通大学附属第一人民医院普外科,上海200080 |
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| 基金项目： | 上海市科委基础研究重点项目（09JC1412400）,上海市科委医学引导项目（10411967300） |
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| 摘 要： | RAS相关结构域家族（Ras Association Domain Family, RASSFs ） 10个成员组成，参与不同的细胞内机制如凋亡、细胞周期控制、微管稳定性等一些家族成员表现出肿瘤抑制功能。目前发现RASSF6在肺癌、宫颈癌等实体瘤中表达下调，可能与肿瘤形成有关，并可作为肿瘤治疗的潜在靶点。本文就RASSF6与肿瘤的研究进展进行综述。
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| 关 键 词： | RASSF6 恶性肿瘤 抑癌基因 |
Advancement of RASSF6 and Malignant Tumors |
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| WEN Yu-gang,WANG Quan,PENG Zhi-hai.Advancement of RASSF6 and Malignant Tumors[J].Biomagnetism,2011(13):2590-2593. |
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| Authors: | WEN Yu-gang WANG Quan PENG Zhi-hai |
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| Institution: | (Shanghai First People＇s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China) |
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| Abstract: | The RAS-association domain family （RASSFs）, as a new Ras effector, consistant of 10 members. Some of the family members are thought to function as tumor suppressors for they have been shown to have a diverse range of functions including cell cycle regulation and the regulation of microtubule stability in addition to roles in the control of apoptosis and proliferation. RASSF6 expression was reduced in lung cancer, cervical cancer and might relate to tumorigenesis. Furthermore, it might be a potential target for tumor therapy. Here we review the current research progress on RASSFs, especially on RASSF6. |
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| Keywords: | RASSF6 Malignant tumor Tumor suppressor gene |
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