活血解毒、益气养阴法治疗狼疮性血管炎临床及免疫研究

目的：观察活血解毒、益气养阴法对狼疮性血管炎临床疗效及免疫功能的影响。方法：选择系统性红斑狼疮患者60例,其中活动期伴血管炎40例,非活动期20例,同时选择20例健康人作为对照组,检测可溶性血栓调节素（sTM）、血管内皮生长因子（VEGF）的水平、抗中性粒细胞胞浆抗体（ANCA）的阳性率;并将40例活动期伴血管炎患者随机分为中西医结合治疗组（狼疮饮＋常规西药）和对照组（常规西药）,治疗6个月后观察临床疗效,并检测治疗前和治疗后第1,6个月sTM、VEGF、ANCA水平和阳性率变化。结果：中西医结合治疗组疗效优于对照组,治疗组治疗后sTM、VEGF、ANCA水平和阳性率下降优于对照组（P〈0.05）。结论：中西医结合治疗可提高狼疮性血管炎的疗效,改善免疫功能。

Effect of Activating the Blood and Detoxifying plus Tonifying the Qi and the Yin on Vasculitis of Lupus Erythematosus

Objective： To observe the effect of Huoxue Jiedu and Yiqi Yangyin method on clinical and immune function with vasculitis of lupus erythematosus. Methods： Sixty patients with systemic lupus erythematosus were recruited including 40 in active phase companion vasculitis and 20 in inactive phase,and 20 healthy persons as control group. The plasma level of sTM , VEGF and ANCA pos- itive were measured.And forty patients with active phase companion vasculitis were divided into combined trentment group （treated with traditional Chinese medicine Langchaungyin and western medicine） and control group （treated with western medicine）. Before treatment and after 1,6 months treatment, clinical effect was observed and the levels and positive of sTM,VEGF and ANCA were detected and compared. Results： The combined treatment group showed a better clinical effect than control group. The serum sTM, VEGF levels and ANCA positive of treatmentgroup were significantly decreasedcompared with control group after1,6months treatment（P0.05）.Concluation： Combined treatment of traditional chinese medicine and western medicine can improve clinical effect and immune function with vasculi- tis of lupus erythematosus patients.