|
|||||
|
|
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists |
|
| Authors: | Orain David Ofner Silvio Koller Manuel Carcache David A Froestl Wolfgang Allgeier Hans Rasetti Vittorio Nozulak Joachim Mattes Henri Soldermann Nicolas Floersheim Philipp Desrayaud Sandrine Kallen Joerg Lingenhoehl Kurt Urwyler Stephan |
| Affiliation: | Novartis Institute for Biomedical Research, Global Discovery Chemistry, Basel CH-4002, Switzerland. david.orain@novartis.com |
| Abstract: | A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED(50) of 5.5mg/kg in an animal model of anticonvulsant activity after oral dosage. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |