甲壳动物胰岛素样促雄腺激素功能及 作用机制的研究进展

甲壳动物的雄性性别分化主要由其促雄腺（AG）分泌的胰岛素样促雄腺激素（IAG）负责调控。在罗氏沼虾（Macrobrachium rosenbergii）中，通过单个IAG的操作可以成功性反转，进而实现全雄养殖。因此，基于IAG的性别调控技术具有良好的应用潜力。目前，IAG在许多经济甲壳动物中得到研究报道，发现其表达不仅局限于促雄腺，功能也更加广泛。此外，随着RNA干扰技术在水产动物中的广泛运用，基因功能的研究更易实现，IAG如何执行其生理作用的信号机制及上游的调控网络逐渐成为学者们探究的热点。本文综述了近年来有关IAG研究的进展，从IAG的分子特征、生理功能、作用机制及上游调控机理等方面展开探讨，为深入阐明IAG的生理功能及作用机制提供基础。

Research Advance in Functions and Related Mechanisms of Insulin-like Androgenic Gland Hormone in Crustaceans

The male sex differentiation in crustaceans is mainly regulated by the insulin-like androgenic gland hormone (IAG) secreted by the androgenic gland (AG). In Macrobrachium rosenbergii, manipulation of the IAG can lead to a full-functional reversed female, which is used to produce all-male offspring. Therefore, the IAG-based sex regulation technique has its application potential. At present, IAG has been reported in many economic crustaceans. It is found that IAG expression is not limited to the AG, and its function is more extensive. With the application of RNA interference technology in aquatic animals, the study of gene function is more easily realized. Therefore, the signaling mechanism of IAG function and its upstream regulatory network have gradually become a hot topic. This paper reviews the recent research progresses in the regulation of gene expression, molecular characteristics and biological functions of IAG, as well as the signaling mechanisms of IAG function. Summary of these researches will provide a basis for further elucidation of the physiological function of IAG, as well as its mode of action.