Antibiotic resistance modulation by natural products obtained from Nasutitermes corniger (Motschulsky, 1855) and its nest |
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| Authors: | Thiago P Chaves Elaine LC Clementino Delcio C Felismino R?mulo RN Alves Alexandre Vasconcellos Henrique DM Coutinho Ana Cláudia D Medeiros |
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| Institution: | 1. Universidade Federal do Piauí, Campus Professora Cinobelina Elvas, Bom Jesus, PI 64900-000, Brazil;2. Laboratório de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba, Campina Grande, Paraíba 58.429-500, Brazil;3. Departamento de Biologia, Centro de Ciências Biológicas e da Saúde, Universidade Estadual da Paraíba, Campina Grande, Paraíba 58.429-500, Brazil;4. Universidade Federal do Rio Grande do Norte, Departamento de Botânica, Ecologia e Zoologia, Natal, RN 59072-900, Brazil;5. Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE 63105-000, Brazil |
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| Abstract: | Insects and their products are included in the traditional pharmacopoeia of various ethnic groups worldwide. In the Brazilian semiarid region can be highlighted the use of the termite Nasutitermes corniger for the treatment of various diseases. This study evaluated the ethanol extract of N. corniger and its nest as an antimicrobial agent and as a modulator of bacterial resistance against multidrug strains. The Minimum Inhibitory Concentration (MIC) of the extract on Staphylococcus aureus and Escherichia coli by microdilution was determined, as well as MIC of antibiotics in the presence and absence of extract. Despite having no significant antimicrobial activity (MIC ? 1000 μg mL?1), the extract showed additive activity to the antibiotic efficacy, significantly reducing its MIC. These results suggest that N. corniger and its nest are promising natural products for use in antimicrobial therapy. |
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| Keywords: | Modification of resistance Synergistic effect Antimicrobial activity Insect Zootherapy Ethnopharmacology |
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