Mammalian RNA virus-derived small RNA: biogenesis and functional activity |
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| Affiliation: | 1. Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan;2. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan;3. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan;4. Clinical Virology Laboratory, Chang Gung Memorial Hospital, Tao-yuan, Taiwan;1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;2. Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA;3. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA;1. The Mahidol Oxford Tropical Medicine Research Unit, Bangkok 10400, Thailand;1. Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus Samambaia, Instituto de Ciências Biológicas II (ICB II), 2º Andar, Sala 206, Goiânia, Goiás, 74690-900, Brazil;2. Departamento de Ciências Fisiológicas, Universidade Federal do Amazonas, Av. General Rodrigo Octávio, 6200, Coroado I, Manaus, Amazonas, 69077-000, Brazil;3. Unidad de Biología Celular y Molecular, Corporación para Investigaciones Biológicas (CIB), Medellín, Calle 62 No. 52-59, 51922, Colombia;4. Facultad de Medicina, Universidad de Antioquia, Medellín, Carrera 51 D No. 62-29, 050010, Colombia |
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| Abstract: | The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field. |
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| Keywords: | vsRNA siRNA RNAi Mammalian RNA virus Small RNA |
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