Modulation of behavior of mice of different genotypes by serotonin antibodies |
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Authors: | Mikovskaia O I Vetrilé L A Trekova N A Basharova L A Evseev V A |
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Institution: | Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. |
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Abstract: | The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour. |
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