Identification of estrogen-inducible growth factors (estromedins) for rat and human mammary tumor cells in culture |
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Authors: | Tatsuhiko Ikeda Qi-fu Liu David Danielpour Jefferson B Officer Masayoshi Iio Frances E Leland David A Sirbasku |
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Institution: | (1) Faculty of Nutrition, Kobe-Gakuin University, Igawadani-cho Arise, Nishi-ku, 673 Kobe, Japan;(2) Department of Biochemistry, Guangxi Medical College, Nanning, Guangxi, People’s Republic of China;(3) Department of Biochemistry and Molecular Biology, The University of Texas Medical School, 77025 Houston, Texas;(4) Kumamoto Women’s University, Kengun-cho, 862 Kumamoto, Japan |
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Abstract: | Summary The role of polypeptide growth factors (estromedins) as mediators of estrogen-responsive mammary tumor growth is studied in
this report. Three possible new mechanisms were investigated that include endocrine, autocrine, and paracrine related growth
factors. The first hypothesis being tested is whether estrogens interact with target tissues and cause the biosynthesis and
secretion of polypeptide growth factors, which then act as mitogens for normal and neoplastic mammary tissues. Data presented
suggest that this mechanism involves estrogen interaction with uterus, kidney, and pituitary gland causing production of growth
factors, which then enter the general circulation and promote growth of distant target tissues. This is an endocrine type
mechanism. Another type of estromedin control (autocrine control) may be exerted in an autostimulatory way in which the target
tissue produces the polypeptide factors for its own growth in response to estrogen stimulation. A variation of the autocrine
mechanism may be a paracrine mechanism in which some cells of an estrogen-responsive normal or neoplastic tissue produce growth
factors that act on adjacent or neighboring cells. From the data available, all three possible types of growth factors could
be functioning synergistically to yield the final result of continuous estrogen responsive tumor growth in vivo.
Presented in the symposium on Plant and Animal Physiology in Vitro at the 33rd Annual Meeting of the Tissue Culture Association,
San Diego, California, June 6–10, 1982.
This work was supported by American Cancer Society Grant BC-255; D. A. S. is the recipient of an American Cancer Society Faculty
Research Award, FRA-212. D. D. is supported by a Rosalie B. Hite predoctoral fellowship from the Rosalie B. Hite Foundation,
Houston, Texas.
This symposium was supported in part by the following organizations: Bellco Glass, Inc., California Branch of the Tissue Culture
Association, Collaborative Research, Hana Media, Hybridtech, K C Biological, Inc., and Millipore Corporation. |
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Keywords: | estrogens tumor growth growth factors mammary gland uterus kidney pituitary tumors |
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