A comparative study of serum selenium and vitamin E levels in a population of male risk drinkers and abstainers |
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Authors: | Jetmund Ringstad Synnøve F Knutsen Odd R Nilssen Yngvar Thomassen |
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Institution: | 1. ?stfold Central Hospital, N-1700, Sarpsborg, Norway 2. The Institute of Community Medicine, University of Troms?, Norway 3. National Institute of Occupational Health, Oslo, Norway
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Abstract: | Depressed selenium and Vitamin E levels may contribute to hepatic injury through lipid peroxidation. To study the effect of
moderate alcohol drinking (32.4±23.6 g ethanol/d) on serum selenium and serum vitamin E concentrations, we conducted a matched-pair
study of 73 healthy, well-nourished risk drinkers and healthy controls with little or no alcohol consumption. Among risk drinkers,
serum selenium was significantly lowered (1.49 vs 1.67 μmol/L;p<0.001) compared with controls. Difference in α-tocopherol concentrations did not, however, reach statistical significance
(22.8 vs 24.9 μmol/L;p=0.06). Nutritional and life-style factors differed very little between the two groups. We conclude that even moderate alcohol
consumption lowers selenium status. Selenium may thus represent a link joining the hepatotoxic and nutritional backgrounds
of alcoholic liver disease. |
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Keywords: | Selenium α -tocopherol alcohol liver disease |
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