Effect of hydroxypropyl methylcellulose and hydrogenated castor oil on naproxen release from sustained-release tablets |
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Authors: | M Helena Amaral J M Sousa Lobo D C Ferreira |
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Institution: | (1) Centro de Tecnologia do Medicamento, Faculty of Pharmacy, University of Oporto, Rua Aníbal Cunha, 164, 4050 Porto, Portugal;(2) Centro de Tecnologia do Medicamento, Faculdade de Farmácia do Porto, Rua Aníbal Cunha, 164, 4050 Porto, Portugal |
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Abstract: | The effect of the concentration of hydrophilic (hydroxypropyl methylcellulose HPMC]) and hydrophobic (hydrogenated castor
oil HCO]) products, fillers (lactose and dibasic calcium phosphate), and buffers (sodium bicarbonate, calcium carbonate,
and sodium citrate) on naproxen release rate was studied. Matrix tablets were prepared by double compression, andIn vitro dissolution tests were performed. The dissolution results showed that an increased amount of HPMC or hydrogenated castor
oil resulted in reduced drug release. The inclusion of buffers in the HPMC matrix tablets enhanced naproxen release. For HCO
tablets, only sodium bicarbonate enhanced naproxen release. The presence of lactose on HPMC matrix tablets did not show a
significantly different result from that obtained with the formulation containing dibasic calcium phosphate as a filler. However,
for the tablets containing HCO, the presence of lactose significantly enhanced the naproxen release rate. The matrix-forming
materials in this study were suitable for use in sustained-release tablets containing naproxen. The drug release can be modulated
by adding suitable amounts of diluents and buffers. |
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Keywords: | Naproxen Sustained-release Hydrophilic matrix Lipidic matrix |
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