A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila |
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| Authors: | Brassinga Ann Karen C Hiltz Margot F Sisson Gary R Morash Michael G Hill Nathan Garduno Elizabeth Edelstein Paul H Garduno Rafael A Hoffman Paul S |
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| Affiliation: | Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7. |
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| Abstract: | Nucleotide sequence analysis of an approximately 80-kb genomic region revealed an approximately 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this approximately 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains. |
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