From evidence-based medicine to genomic medicine |
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Authors: | Kumar Dhavendra |
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Institution: | (1) Institute of Medical Genetics, University Hospital of Wales, Cardiff University, Cardiff, CF14 4XN, UK |
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Abstract: | The concept of ‘evidence-based medicine’ dates back to mid-19th century or even earlier. It remains pivotal in planning, funding
and in delivering the health care. Clinicians, public health practitioners, health commissioners/purchasers, health planners,
politicians and public seek formal ‘evidence’ in approving any form of health care provision. Essentially ‘evidence-based
medicine’ aims at the conscientious, explicit and judicious use of the current best evidence in making decisions about the
care of individual patients. It is in fact the ‘personalised medicine’ in practice. Since the completion of the human genome
project and the rapid accumulation of huge amount of data, scientists and physicians alike are excited on the prospect of
‘personalised health care’ based on individual’s genotype and phenotype. The first decade of the new millennium now witnesses
the transition from ‘evidence-based medicine’ to the ‘genomic medicine’. The practice of medicine, including health promotion
and prevention of disease, stands now at a wide-open road as the scientific and medical community embraces itself with the
rapidly expanding and revolutionising field of genomic medicine. This article reviews the rapid transformation of modern medicine
from the ‘evidence-based medicine’ to ‘genomic medicine’. |
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Keywords: | Genetics Genomics Evidence-based medicine Genomic medicine Personalised medicine Pharmacogenetics Pharmacogenomics Nutrigenomics |
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