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FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology
Authors:Nakajima Oumi  Nakamura Fumio  Yamashita Naoya  Tomita Yusuke  Suto Fumikazu  Okada Takako  Iwamatsu Akihiro  Kondo Eisaku  Fujisawa Hajime  Takei Kohtaro  Goshima Yoshio
Affiliation:Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Abstract:
FK506-binding proteins are the peptidyl prolyl cis-trans isomerases that are involved in various intracellular events. We characterized a novel mouse FK506-binding protein homolog, FKBP133/KIAA0674, in the developing nervous system. FKBP133 contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) and a domain homologous to FK506-binding protein motif. FKBP133 was predominantly expressed in cerebral cortex, hippocampus, and peripheral ganglia at embryonic day 18.5. FKBP133 protein was distributed in the axonal shafts and was partially co-localized with F-actin in the growth cones of dorsal root ganglion neurons (DRG). The number of filopodia was increased in the DRG neurons overexpressing FKBP133. In contrast, the overexpression of a mutant deleted the WH1 domain reduced the growth cone size and the number of filopodia. Furthermore, the neurons overexpressing FKBP133 became significantly resistant to Semaphorin-3A induced collapse response. These results suggest that FKBP133 modulates growth cone behavior with the WH1 domain.
Keywords:FK506-binding protein   PPIase   WH1   FKBP133   KIAA0674   Sema3A   Plexin   Nervous system   Development
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