抗血管生成治疗实体肿瘤正常化期间微环境对血液灌注的影响

目的 研究实体肿瘤抗肿瘤血管生成治疗作用下,血管正常化期肿瘤血管微环境动力学参数的变化（包括渗透率、水力传导系数、胶体渗透压、表面积与体积的比例和血管管径）对血液灌注的影响.方法 数值模拟肿瘤血管止常化期过程中的血液灌注.设血液为不可压缩牛顿流体,肿瘤内间质流动遵循Darcy定律,管内流量用扩展的Poiseuille定律,跨壁流量采用Starling定律.用差分迭代法数值计算肿瘤血液灌注组织间质压强.结果 在＂血管止常化窗口期＂,肿瘤组织间质压强下降,压强梯度增大.结论 抗血管生成治疗不仅抑制了肿瘤血管生成,而且随肿瘤血管血液动力学参数的变化,在＂血管正常化窗口期＂改善了肿瘤血液动力学环境,有利于其他治疗肿瘤药物的输运.抗肿瘤血管生成和其它方法联合可望有较好的疗效.

Research on the Effect of Microenvironment of Tumor Blood Perfusion under Anti-angiogenesis Therapy

Objective Study the effect of changing Microenvironment(including permeability,hydraulic conductivity,oncotic pressure,surface area to volume ratio and tumor radius) due to anti-angiogenesis therapy on the blood perfusion of solid tumors.Methods Numerical simulate the blood perfusion of tumor under the effect of ES during thenormalization window.We assume blood as incompressible Newtonian flow and interstitial flow follows Darcy's law while vascular flow rate and transvascular flow rate abide by extended Po...