c-Kit--a hematopoietic cell essential receptor tyrosine kinase |
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| Authors: | Edling Charlotte E Hallberg Bengt |
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| Affiliation: | 1. Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;2. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Institute of Cell Biology, Medical University of Innsbruck, Biocenter, Innsbruck, Austria;1. Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre “Giovanni Paolo II”, Bari, Italy;2. Department of Prevention and Animal Health, ASL BAT, Barletta, Bari, Italy;3. Chair of Pathology, Veterinary Medical School, University of Bari, Valenzano, Bari, Italy;4. Pathology Unit, ASL BA, Bari, Italy;1. Univ Lille Nord de France, F-59000 Lille, France;2. Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), UDSL, EA4481, F-59006 Lille, France;1. Minneapolis Radiation Oncology, Minneapolis, Minnesota;2. MD Anderson Cancer Center, Houston, Texas;3. University of California San Francisco, San Francisco, California;4. Massachusetts General Hospital, Boston, Massachusetts;6. Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota;5. Memorial Sloan Kettering Cancer Center, New York, New York;7. US Oncology, Minneapolis, Minnesota;11. Duke University, Durham, North Carolina;12. University of Colorado Denver, Denver, Colorado;8. University of Maryland, Baltimore, Maryland;10. Centre Hospitalier de l''Universite de Montreal, Montreal, Quebec, Canada;9. Yale University, New Haven, Connecticut |
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| Abstract: | The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for proliferation, survival and differentiation. During recent years exploration of the signalling pathways downstream of this receptor has yielded significant new insights in the field. In this review, we will summarise the c-Kit background, structure, downstream signalling and medical significance with particular focus on its role in hematopoietic progenitor cells and mast cells. |
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| Keywords: | Receptor tyrosine kinase c-Kit Hematopoietic cells PI-3 kinase |
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