| 肺炎克雷伯菌噬菌体解聚酶的研究进展 |
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| 引用本文： | 刘源平,王兆飞,孙爱喜,孙建和.肺炎克雷伯菌噬菌体解聚酶的研究进展[J].微生物学通报,2021,48(9):3281-3292. |
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| 作者姓名： | 刘源平 王兆飞 孙爱喜 孙建和 |
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| 作者单位： | 上海交通大学农业与生物学院 上海市兽医生物技术重点实验室 上海 200240;上海元宋生物技术有限公司 上海 201401 |
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| 基金项目： | 国家重点研发计划“合成生物学”重点专项（2019YFA0904000）；国家自然科学基金（31772744） |
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| 摘 要： | 肺炎克雷伯菌（Klebsiella pneumoniae）是在临床引起多种感染的常见条件致病菌之一。多重耐药肺炎克雷伯菌株的出现，给防控细菌感染带来了巨大阻力。肺炎克雷伯菌噬菌体编码的解聚酶是一种稳定性高、特异性强的生物酶，具有分解细菌胞外多糖、限制细菌生长等多种功能。解聚酶可为防控肺炎克雷伯菌感染提供新思路，在抗菌应用中具有广阔前景。本文就肺炎克雷伯菌噬菌体解聚酶的研究进展进行综述。
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| 关 键 词： | 肺炎克雷伯菌 噬菌体 解聚酶 抗生素耐药性 抗菌应用 |
| 收稿时间： | 2021/6/1 0:00:00 |
Advance in the depolymerase employed by Klebsiella pneumoniae phage |
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| LIU Yuanping,WANG Zhaofei,SUN Aixi,SUN Jianhe.Advance in the depolymerase employed by Klebsiella pneumoniae phage[J].Microbiology,2021,48(9):3281-3292. |
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| Authors: | LIU Yuanping WANG Zhaofei SUN Aixi SUN Jianhe |
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| Institution: | School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai 200240, china;Shanghai Yuansong Biotechnology Company Limited, Shanghai 201401, China |
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| Abstract: | Klebsiella pneumoniae is one of the common pathogenic bacteria that causes a variety of clinical infections. The emergence of multi-drug resistant Klebsiella pneumoniae strains has brought numerous obstacles in prevention and control of bacterial infections. The depolymerase encoded by Klebsiella pneumoniae phage is a biological enzyme with high stability and strong specificity. It has many functions such as decomposing bacterial extracellular polysaccharides and restricting the bacterial growth, etc. The depolymerase provides new ideas to prevent and control Klebsiella pneumoniae infection and has broad prospects in antibacterial applications. This article reviews the advance of depolymerase employed by phage of Klebsiella pneumoniae. |
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| Keywords: | Klebsiella pneumoniae phage depolymerase antibiotic resistance antibacterial application |
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