Observations on the Vietnam Palo Alto strain of Plasmodium vivax in two species of Aotus monkeys |
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Authors: | Collins William E Sullivan JoAnn S Galland G Gale Williams Allison Nace Douglas Williams Tyrone Barnwell John W |
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Institution: | Division of Parasitic Disease and Animal Resources Branch, National Center for Infectious Disease, Atlanta, Georgia 30341, USA. wec1@cdc.gov |
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Abstract: | Thirty-three splenectomized Aotus lemurinus griseimembra monkeys with no previous experience with malaria were infected with the Vietnam Palo Alto strain of Plasmodium vivax. The median maximum parasite count was 280,000/microl. Nine splenectomized monkeys with previous infection with Plasmodium falciparum had median maximum parasite counts of 120,000/microl. Splenectomized Aotus nancymai monkeys supported infections at a lower level. Transmission via the bites of Anopheles dirus mosquitoes was obtained in a splenectomized A. lemurinus griseimembra, with a prepatent period of 31 days. It is estimated that between 1.5 x 10(8) and 1.6 x 10(9) parasites can be removed from an infected animal for molecular or diagnostic antigenic studies. |
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