Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides |
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| Authors: | Obika S Morio K Hari Y Imanishi T |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Japan. |
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| Abstract: | Bicyclic nucleoside analogues, 3'-O,4'-C-methyleneuridine and -5-methyluridine, were successfully incorporated into oligonucleotides via connection with 2',5'-phosphodiester linkage, and hybridization behavior and nuclease stability of the modified oligonucleotides were investigated. |
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