Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage |
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| Authors: | RP Tucker K Drabikowski JF Hess J Ferralli R Chiquet-Ehrismann JC Adams |
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| Affiliation: | (1) Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA;(2) Friedrich Miescher Institute, Novartis Research Foundation, Basel, Switzerland;(3) Dept. of Cell Biology, Lerner Research Institute and Dept. of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44118, USA;(4) Institute of Biology 3, University of Freiburg, Freiburg, Germany |
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| Abstract: | Background Tenascins are a family of glycoproteins found primarily in the extracellular matrix of embryos where they help to regulate cell proliferation, adhesion and migration. In order to learn more about their origins and relationships to each other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis, the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously characterized tenascins of amniotes. |
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