The Bacillus anthracis cholesterol-dependent cytolysin, Anthrolysin O, kills human neutrophils, monocytes and macrophages |
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| Authors: | Elise M Mosser and Richard F Rest |
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| Institution: | (1) Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, USA |
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| Abstract: | Background
Bacillus anthracis is an animal and human pathogen whose virulence is characterized by lethal and edema toxin, as well as a poly-glutamic acid
capsule. In addition to these well characterized toxins, B. anthracis secretes several proteases and phospholipases, and a newly described toxin of the cholesterol-dependent cytolysin (CDC) family,
Anthrolysin O (ALO). |
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