Multicellular Tumour Spheroid as a model for evaluation of [<sup>18</sup>F]FDG as biomarker for breast cancer treatment monitoring期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Multicellular Tumour Spheroid as a model for evaluation of [¹⁸F]FDG as biomarker for breast cancer treatment monitoring

Authors:	Azita Monazzam Pasha Razifar Martin Simonsson Fredrik Qvarnstr?m Raymond Josephsson Carl Blomqvist Bengt L?ngstr?m Mats Bergstr?m

Affiliation:	(1) Department of Oncology, , Radiology and Clinical Immunology, Uppsala University, SE-751 85 Uppsala, Sweden;(2) Uppsala University, Centre for Image Analysis, Lgerhyddsvgen 3, SE-752 37 Uppsala, Sweden;(3) Department of Pharmaceutical Biosciences, Uppsala University, Sweden;(4) Uppsala Imanet AB (PET Center), BOX 967, Sweden;(5) Novartis Pharma AG, Clinical Imaging, CH-4002 Basel, Switzerland;(6) Department of medical Science, The Academic Hospital, S-751 85 Uppsala, Sweden

Abstract:	Background In order to explore a pre-clinical method to evaluate if [¹⁸F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with five routinely used chemotherapy agents in breast cancer.

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