Similar and divergent features in mammalian and yeast prions |
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Authors: | Bousset Luc Melki Ronald |
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Institution: | Laboratoire d'enzymologie et biochimie structurales, CNRS, Bat. 34, avenue de la Terrasse, 91198 Gif-sur-Yvette, France. |
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Abstract: | Mammalian transmissible spongiform encephalopathies are likely due to the propagation of an abnormal form of a constitutive protein instead of traditional genetic material (nucleic acids). Such infectious proteins, which are termed prions, exist in yeast. They are at the origin of a number of phenotypes that are inherited in a non-Mendelian manner. These prions are very useful to dissect the molecular events at the origin of this structure-based inheritance. The properties of mammalian and yeast prions are presented and compared. This review highlights a number of similarities and differences. |
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