Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain |
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| Authors: | Gabriela V Meirelles Júlio C Silva Yuri de A Mendonça Carlos HI Ramos Iris L Torriani Jörg Kobarg |
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| Institution: | 1.Laboratório Nacional de Biociências,Centro Nacional de Pesquisa em Energia e Materiais,Campinas,Brazil;2.Departamento de Bioquímica-Programa de Pós-gradua??o em Biologia Funcional e Molecular,Instituto de Biologia, Universidade Estadual de Campinas,Campinas,Brazil;3.Instituto de Química,Universidade Estadual de Campinas,Campinas,Brazil;4.Laboratório Nacional de Luz Síncrotron,Centro Nacional de Pesquisa em Energia e Materiais,Campinas,Brazil;5.Instituto de Física "Gleb Wataghin",Universidade Estadual de Campinas,Campinas,Brazil |
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| Abstract: | Background The NIMA-related kinases (Neks) are widespread among eukaryotes. In mammalians they represent an evolutionarily conserved
family of 11 serine/threonine kinases, with 40-45% amino acid sequence identity to the Aspergillus nidulans mitotic regulator NIMA within their catalytic domains. Neks have cell cycle-related functions and were recently described
as related to pathologies, particularly cancer, consisting in potential chemotherapeutic targets. Human Nek6, -7 and -9 are
involved in the control of mitotic spindle formation, acting together in a mitotic kinase cascade, but their mechanism of
regulation remain elusive. |
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