In vitro secretion and activity profiles of matrix metalloproteinases,MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli |
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| Authors: | Veronica Zaga-Clavellina Guadalupe Garcia-Lopez Arturo Flores-Pliego Horacio Merchant-Larios Felipe Vadillo-Ortega |
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| Affiliation: | 1.Biomedical Research Branch,Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes",Mexico City,Mexico;2.Direction of Research,,Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes",Mexico City,Mexico;3.Biomedical Research Institute,School of Medicine, Universidad Nacional Autónoma de México,Mexico City,Mexico;4.Departament of Experimental Medicine,School of Medicine, Universidad Nacional Autónoma de México,Mexico City,Mexico |
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| Abstract: | Background Premature rupture of fetal membranes (PROM) complicated with intrauterine infection has been associated to alterations of the extracellular matrix (ECM) homeostasis. The aim of this work was to evaluate the integral/functional response of the amnion (AMN) and choriodecidua (CHD) to synthesis, secretion, and activity of MMP-2 and MMP-9 and of their inhibitors TIMP-1, -2, and -4, after stimulation with Escherichia coli. |
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