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| OPG/RANK/RANKL系统与骨质疏松研究最新进展 | |
| 引用本文： | 孔祥鹤,牛银波,李宇华,梅其炳. OPG/RANK/RANKL系统与骨质疏松研究最新进展[J]. 生命科学研究, 2011, 15(1): 80-85 |
| 作者姓名： | 孔祥鹤 牛银波 李宇华 梅其炳 |
| 作者单位： | 1. 西北工业大学生命学院,中国陕西,西安,710072 2. 第四军医大学药理教研室,中国陕西,西安,710032 3. 西北工业大学生命学院,中国陕西,西安,710072;第四军医大学药理教研室,中国陕西,西安,710032 |
| 基金项目： | 国家自然科学基金资助项目(81073037); 国家高技术研究发展计划项目(863计划)(2008AA12A220); 西北工业大学博士论文创新基金资助项目(cx201024) |
| 摘 要： | 骨质疏松是严重威胁中老年人健康的骨科常见病,OPG/RANK/RANKL是参与调节骨重建的最重要的分子系统之一,与骨疾病相关的骨质疏松有密切联系,并已成为药物设计的新靶点.因此,对该系统的深入研究将为骨生理、病理机制阐明及骨疾病防治带来积极影响. |
| 关 键 词： | 骨质疏松 骨重建 骨保护蛋白(OPG) 核因子-κβ受体活化因子(RANK) 核因子-κβ受体活化因子配体(RANKL) |
Progress of Research on the Relationship Between OPG/RANK/RANKL System and Osteoporosis |
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| KONG Xiang-he,NIU Yin-bo,LI Yu-hua,MEI Qi-bing. Progress of Research on the Relationship Between OPG/RANK/RANKL System and Osteoporosis[J]. Life Science Research, 2011, 15(1): 80-85 | |
| Authors: | KONG Xiang-he NIU Yin-bo LI Yu-hua MEI Qi-bing |
| Affiliation: | KONG Xiang-he1,NIU Yin-bo1,LI Yu-hua2,MEI Qi-bing1,2(1.College of Life Sciences,Northwestern Polytechnical University,Xi'an 710072,Shaanxi,China,2.Department of Pharmacology,Fourth Military Medical University,Xi'an 710032,China) |
| Abstract: | Osteoporosis is a worldwide health problem with a high prevalence that affects many aged people.OPG/RANK/RANKL system has attributed a decisive role in regulating bone remodeling and their dramatic role in bone disease was largely unexpected.The system has been targeted as a new strategy for the treatment of osteoporosis.Therefore,deep research on this system will make positive effect on expound-ing the mechanisms in normal and pathological conditions,and preventing bone disease. |
| Keywords: | osteoporosis bone remodeling osteoprotegerin(OPG) receptor-activator of nuclear factor kappa beta(RANK) receptor-activator of nuclear factor kappa beta ligand(RANKL) |
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