Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function |
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| Authors: | Singh Mona P Shaw Robert K Knutton Stuart Pallen Mark J Crepin Valerie F Frankel Gad |
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| Affiliation: | Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom. |
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| Abstract: | ![]()
Enteropathogenic Escherichia coli employs a filamentous type III secretion system, made by homopolymerization of the translocator protein EspA. In this study, we have shown that the N-terminal region of EspA has a role in EspA's protein stability, interaction with the CesAB chaperone, and filament biogenesis and function. |
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