Pretreatment CT and PET radiomics predicting rectal cancer patients in response to neoadjuvant chemoradiotherapy |
| |
Authors: | Zhigang Yuan Marissa Frazer Anupam Rishi Kujtim Latifi Michal R Tomaszewski Eduardo G Moros Vladimir Feygelman Seth Felder Julian Sanchez Sophie Dessureault Iman Imanirad Richard D Kim Louis B Harrison Sarah E Hoffe Geoffrey G Zhang Jessica M Frakes |
| |
Institution: | 1.Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, United States; 2.Department of GI Oncology, Moffitt Cancer Center, Tampa, Florida, United States; 3.Department of Radiology, Moffitt Cancer Center, Tampa, Florida, United States |
| |
Abstract: | BackgroundThe purpose of this study was to characterize pre-treatment non-contrast computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (PET) based radiomics signatures predictive of pathological response and clinical outcomes in rectal cancer patients treated with neoadjuvant chemoradiotherapy (NACR T).Materials and methodsAn exploratory analysis was performed using pre-treatment non-contrast CT and PET imaging dataset. The association of tumor regression grade (TRG) and neoadjuvant rectal (NAR) score with pre-treatment CT and PET features was assessed using machine learning algorithms. Three separate predictive models were built for composite features from CT + PET.ResultsThe patterns of pathological response were TRG 0 (n = 13; 19.7%), 1 (n = 34; 51.5%), 2 (n = 16; 24.2%), and 3 (n = 3; 4.5%). There were 20 (30.3%) patients with low, 22 (33.3%) with intermediate and 24 (36.4%) with high NAR scores. Three separate predictive models were built for composite features from CT + PET and analyzed separately for clinical endpoints. Composite features with α = 0.2 resulted in the best predictive power using logistic regression. For pathological response prediction, the signature resulted in 88.1% accuracy in predicting TRG 0 vs. TRG 1–3; 91% accuracy in predicting TRG 0–1 vs. TRG 2–3. For the surrogate of DFS and OS, it resulted in 67.7% accuracy in predicting low vs. intermediate vs. high NAR scores.ConclusionThe pre-treatment composite radiomics signatures were highly predictive of pathological response in rectal cancer treated with NACR T. A larger cohort is warranted for further validation. |
| |
Keywords: | rectal cancer CT PET radiomics neoadjuvant chemoradiation therapy pathologic response |
|
|