肢体负压对犬后肢动脉闭塞病影响的实验研究

目的为研究肢体负压疗法的疗效及探讨其作用机理，我们对犬后肢进行实验研究。方法。实验犬分三组，治疗组为左后肢缺血模型犬并行患者肢负压治疗；对照组同治疗组但不做治疗：自身对照组为双后肢缺血模型犬，左侧行负压治疗，右侧作为对照。

The Experimental Study on the Effects of Leg Negative Pressure for Canine Ischemic Limb

Objective;To determine the effects of leg negative pressure(LNP) for ischemic extremity in dogs. Methods; By cutting the branch of femoral artery and inserting foreign bodies into the artery of canine posterior limb, extremity ischemic models were established. Fifteen dogs were randomly divided into 3 groups and 5 in each group. Only left hind limb was ischemic in control group and treated group whose ischemic limb was treated with LNP( - 12kPa). In self- control group, there were two ischemic limbs, in which the left got treated, while the right did not. Using SPECT(Single Photon Emission Computed Tomography) and RIA(Radio Immunnessay)method, we respectively measured the blood volume of hind limb and plasma 6 - keto - PGF1a, TXB2 before and after treatment. Results ;The blood volume of lesion limb increased in treated group(p < 0.05) and self - control group( p < 0.01). The ratio of plasma 6 - keto - PGFla to TXB2 also rose in treated and self- control group(p < 0.05). Conclusion: The application of LNP on ischemic limb, appear to increase blood supply. That could account partially for the mechanisms that the response to treatment of LNP is good for extensive arterial occlusive diseases of extremity.