Dinitrosyl iron complexes with glutathione in rat myocardial tissue during regional ischemia and postischemic reperfusion |
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Authors: | A A Timoshin O I Pisarenko O V Tskitishvili L I Serebryakova I M Studneva D Yu Drobotova E K Ruuge A F Vanin |
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Institution: | 1.Russian Cardiology Research Center,Moscow,Russia;2.Semenov Institute of Chemical Physics,Russian Academy of Sciences,Moscow,Russia |
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Abstract: | Injection of dinitrosyl iron complexes with glutathione at the onset of 40-min regional myocardial ischemia in rat was shown
to exert a clear cardioprotective action by decreasing the infarct size and suppressing the cardiac rhythm disturbance. After
introducing the preparation, its effective accumulation with protein thiol-containing ligands in the myocardial tissue was
registered be the EPR method. It was also found that in postischemic reperfusion, the rate of decrease in the content of these
complexes in the ischemic area increases, which reflects effective scavenging of short-lived reactive oxygen species by the
dinitrosyl iron complexes. |
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