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The Na+-K+-pump, energy metabolism, and obesity
Authors:T Clausen  O Hansen
Affiliation:Institute of Physiology, University of Aarhus, 8000 Århus C, Denmark
Abstract:In intact soleus and extensor digitorum longus muscles obtained from lean and obese mice, the number of [3H]-ouabain binding sites showed no significant difference. In the same muscles obtained from obese mice, the Na+-K+-pump mediated [42K]-uptake was respectively 39 and 33% larger than in those of lean littermates. This together with the earlier observation that intact muscles require at most 6% of their basal energy production for active Na+-K+-transport indicates that this process is of no quantitative importance for development of obesity.
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