Identification and phylogenetic classification of eleven putative P-type calcium transport ATPase genes in the yeastsSaccharomyces cerevisiae andSchizosaccharomyces pombe |
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| Authors: | P Catty A Goffeau |
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| Institution: | (1) Laboratorie de Biophysique Moleculaire et Cellulaire, DBMS-BMC, CEA, F-38054 Grenoble Cedex 9, France;(2) Unité de Biochimie Physiologique, Université Catholique de Louvain, Place Croix du Sud 2-20, B-1348 Louvain-La-Neuve, Belgium |
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| Abstract: | Calcium is an essential second messenger in yeast metabolism and physiology. So far, only four genes coding for calcium translocating ATPases had been discovered in yeast. The recent completion of the yeastSaccharomyces cerevisiae genome allowed us to identify six new putative Ca++-ATPases encoding genes. Protein sequence homology analysis and phylogenetic classification of all putative Ca++-ATPase gene products from the yeastsSaccharomyces cerevisiae andSchizosacchraomyces pombe reveal three clusters of homologous proteins. Two of them comprises seven proteins which might belong to a new class of P-type ATPases of unknown subcellular location and of unknown physiological function. |
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| Keywords: | Yeast Ca++-ATPases phylogenetic tree calcium |
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